Structure of PDB 4v06 Chain B Binding Site BS01

Receptor Information
>4v06 Chain B (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAM
GYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKY
CGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCT
QYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDE
DVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKA
FDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNP
YTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain4v06 Chain B Residue 1491 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4v06 Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
Resolution2.63 Å
Binding residue
(original residue number in PDB)		H318 H323 E363
Binding residue
(residue number reindexed from 1)		H169 H174 E214
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H318 H323 E363 S382
Catalytic site (residue number reindexed from 1) H169 H174 E214 S233
Enzyme Commision number 1.14.16.4: tryptophan 5-monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0009072 aromatic amino acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4v06, PDBe:4v06, PDBj:4v06
PDBsum4v06
PubMed
UniProtQ8IWU9|TPH2_HUMAN Tryptophan 5-hydroxylase 2 (Gene Name=TPH2)

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