Structure of PDB 4umn Chain B Binding Site BS01

Receptor Information
>4umn Chain B (length=93) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIATKRLY
DEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
Ligand information
Receptor-Ligand Complex Structure
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PDB4umn Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.
Resolution1.99 Å
Binding residue
(original residue number in PDB)		F55 Y56 Q59
Binding residue
(residue number reindexed from 1)		F38 Y39 Q42
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4umn, PDBe:4umn, PDBj:4umn
PDBsum4umn
PubMed25115702
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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