Structure of PDB 4u8d Chain B Binding Site BS01

Receptor Information
>4u8d Chain B (length=172) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCR
LMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQ
KALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRR
DTAQQGVVNFPYDDFIQCVMSV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4u8d Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4u8d INVESTIGATING THE CONFORMATIONAL CHANGES of SORCIN TO SHED LIGHT ON SIGNAL TRANSDUCTION IN THE APOPTOTIC PROCESS
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D83 D85 S87 T89
Binding residue
(residue number reindexed from 1)		D57 D59 S61 T63
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) F95 G118 V120
Catalytic site (residue number reindexed from 1) F69 G92 V94
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0005102 signaling receptor binding
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044325 transmembrane transporter binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0001508 action potential
GO:0006816 calcium ion transport
GO:0006880 intracellular sequestering of iron ion
GO:0006942 regulation of striated muscle contraction
GO:0007165 signal transduction
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0008016 regulation of heart contraction
GO:0010459 negative regulation of heart rate
GO:0010649 regulation of cell communication by electrical coupling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051924 regulation of calcium ion transport
GO:0055118 negative regulation of cardiac muscle contraction
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0086004 regulation of cardiac muscle cell contraction
GO:1901077 regulation of relaxation of muscle
GO:1901841 regulation of high voltage-gated calcium channel activity
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031982 vesicle
GO:0033017 sarcoplasmic reticulum membrane
GO:0042584 chromaffin granule membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4u8d, PDBe:4u8d, PDBj:4u8d
PDBsum4u8d
PubMed
UniProtP30626|SORCN_HUMAN Sorcin (Gene Name=SRI)

[Back to BioLiP]