Structure of PDB 4tk1 Chain B Binding Site BS01

Receptor Information
>4tk1 Chain B (length=401) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFP
ASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPC
GADAVVQVEDTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGP
SEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRST
LLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEK
DYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPV
SAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILT
WHHQEPLPWAQSTGLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGR
L
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4tk1 Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D327 F330 R653 P654 I656 Y673 M711 L712 P713 Y719 V727 D729
Binding residue
(residue number reindexed from 1)		D8 F11 R324 P325 I327 Y344 M376 L377 P378 Y384 V392 D394
Enzymatic activity
Enzyme Commision number 2.10.1.1: molybdopterin molybdotransferase.
2.7.7.75: molybdopterin adenylyltransferase.
Gene Ontology
Biological Process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0032324 molybdopterin cofactor biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:4tk1, PDBe:4tk1, PDBj:4tk1
PDBsum4tk1
PubMed25531214
UniProtQ03555|GEPH_RAT Gephyrin (Gene Name=Gphn)

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