Structure of PDB 4rxh Chain B Binding Site BS01

Receptor Information

>4rxh Chain B (length=421) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLPKMVEGVFSSEIDKQIQATTKFRKLLSKERNPPIEEVIKTGVVGRFVE
FLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPD
VREQAVWALGNIAGDSPQCRDYVLSCGALRPLLTLLGDSRKLSMLRNATW
TLSNFCRGKTPQPDWNTIAPALPVLAKLVYSLDDEVLIDACWAISYLSDG
SNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVI
INCGALPCLLSLLSSNKDGIRKEACWTISNITAGNSAQIQSVIDANIIPP
LIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIKPLCDLL
ACPDNKIIQVALDGLENILKVGELDKNAASINRYALFIEECGGMEKIHDC
QTNANEEIYMKAYNIIEKYFS

Ligand information

>4rxh Chain A (length=5) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KKRKV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4rxh Structure of Importin-alpha from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal.
Resolution	1.7553 Å
Binding residue (original residue number in PDB)	D280 G281 N283 T322 G323 W357 N361 A364 E396 W399 N403
Binding residue (residue number reindexed from 1)	D199 G200 N202 T241 G242 W276 N280 A283 E315 W318 N322

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:4rxh, PDBe:4rxh, PDBj:4rxh
PDBsum	4rxh
PubMed	26091498
UniProt	Q9C2K9

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