Structure of PDB 4rkg Chain B Binding Site BS01

Receptor Information

>4rkg Chain B (length=46) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KPKCRCGISGSSNTLTTCRNSRCPCYKSYNSCAGCHCVGCKNPHKE

Ligand information

>4rkg Chain I (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcgcgcgcgcgc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4rkg Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	C525 R526 C527 N534 R543 P545
Binding residue (residue number reindexed from 1)	C4 R5 C6 N13 R22 P24
Binding affinity	PDBbind-CN: Kd=25.7uM

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0061630	ubiquitin protein ligase activity

	Cellular Component
GO:0072487	MSL complex

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4rkg, PDBe:4rkg, PDBj:4rkg
PDBsum	4rkg
PubMed	25452275
UniProt	P50534\|MSL2_DROME E3 ubiquitin-protein ligase msl-2 (Gene Name=msl-2)

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