Structure of PDB 4ri5 Chain B Binding Site BS01

Receptor Information
>4ri5 Chain B (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNADTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKN
RYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT
CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQC
QSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPEHGVPDDSSDFLEF
VNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIV
RKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQ
Ligand information
Ligand IDVN4
InChIInChI=1S/3O.V/q;;-1;
InChIKeyALTWGIIQPLQAAM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[O-][V](=O)=O
FormulaO3 V
Nameoxido(dioxo)vanadium
ChEMBL
DrugBank
ZINC
PDB chain4ri5 Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ri5 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Resolution1.26 Å
Binding residue
(original residue number in PDB)		C842 S843 A844 G845 I846 G847 R848
Binding residue
(residue number reindexed from 1)		C218 S219 A220 G221 I222 G223 R224
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E811 C842 R848 T849 Q886
Catalytic site (residue number reindexed from 1) E187 C218 R224 T225 Q262
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ri5, PDBe:4ri5, PDBj:4ri5
PDBsum4ri5
PubMed25728925
UniProtP26045|PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (Gene Name=PTPN3)

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