Structure of PDB 4rhl Chain B Binding Site BS01

Receptor Information
>4rhl Chain B (length=299) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFSKFLMNVKGVTPRGSDWANRLGPVALFGYGAGMPRRAPLLDFFLQSPR
DCDHYAELTIHDKGPIECPPMFMPVLNCGQMLDEGTETPTSDEWYLGSLE
ASTELLEKGYVPVSVGGDGSATLSMVEAYKRLFPSDDIVIVHFDAHPSVS
DPRSPLRVLLDKGLLKGVVSVGNRQVSSEDRKVRKLHKMFYMDMHAIYSK
GLFCIRDIRNDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHIMNG
IRGPKVVGIDVYGYNPDLDVYRKDNVGLTAIALSKIIKEGILKAYSIST
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4rhl Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4rhl Crystal Structure of an Arginase-like Protein from Trypanosoma brucei That Evolved without a Binuclear Manganese Cluster.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D149 H151 D224 D226
Binding residue
(residue number reindexed from 1)		D144 H146 D219 D221
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.3.1: arginase.
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0008783 agmatinase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006525 arginine metabolic process
GO:0033389 putrescine biosynthetic process from arginine, using agmatinase

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Molecular Function
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Biological Process
External links
PDB RCSB:4rhl, PDBe:4rhl, PDBj:4rhl
PDBsum4rhl
PubMed25536859
UniProtQ581Y0

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