Structure of PDB 4rea Chain B Binding Site BS01

Receptor Information
>4rea Chain B (length=588) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVR
LFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLE
LLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQGIGAVILKRAKALA
GQSVRICKGPRAVFSRILLLFSLTDSMEDELLVNLGRMEFPSYTINRKTH
IFQDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNH
PSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLL
SQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRL
SLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVKHVTITLCSVEELALAH
YRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLDLC
TDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSWDR
FTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPALVVWNSQSRHF
KLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4rea Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.
Resolution3.81 Å
Binding residue
(original residue number in PDB)		R420 R424 K425 Y436 N621 L811 P979
Binding residue
(residue number reindexed from 1)		R50 R54 K55 Y66 N227 L390 P558
Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4rea, PDBe:4rea, PDBj:4rea
PDBsum4rea
PubMed25500724
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

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