Structure of PDB 4r8m Chain B Binding Site BS01

Receptor Information
>4r8m Chain B (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRGLYDNL
EKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKD
KGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLS
WMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLL
LVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQGMDFDSKKAYRDVAW
LGECDQGCLALAELLGWKKELEDLVRREHASIDAQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4r8m Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies
Resolution2.1 Å
Binding residue
(original residue number in PDB)		V233 F235 E237 F244 V266 Q267
Binding residue
(residue number reindexed from 1)		V176 F178 E180 F187 V209 Q210
Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P41 D42 F43 R44 N111 D113 H130
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4r8m, PDBe:4r8m, PDBj:4r8m
PDBsum4r8m
PubMed25704306
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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