Structure of PDB 4r7p Chain B Binding Site BS01

Receptor Information
>4r7p Chain B (length=485) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSV
DWGKIQRPPEDSIQPYEKIKARGLPDNISSVLNKLVVVKLNGGLGTSMGC
KGPKSLIGVRNENTFLDLTVQQIEHLNKTYNTDVPLVLMNSFNTDEDTKK
ILQKYNHCRVKIYTFNQSRYPRINKESLLPVAKDVSYSGENTEAWYPPGH
GDIYASFYNSGLLDTFIGEGKEYIFVSNIDNLGATVDLYILNHLMNPPNG
KRCEFVMEVTNKTRADVKGGTLTQYEGKLRLVEIAQVPKAHVDEFKSVSK
FKIFNTNNLWISLAAVKRLQEQNAIDMEIIVNAKTLDGGLNVIQLETAVG
AAIKSFENSLGINVPRSRFLPVKTTSDLLLVMSNLYSLNAGSLTMSEKRE
FPTVPLVKLGSSFTKVQDYLRRFESIPDMLELDHLTVSGDVTFGKNVSLK
GTVIIIANHGDRIDIPPGAVLENKIVSGNLRILDH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4r7p Chain B Residue 609 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4r7p A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		N179 H180
Binding residue
(residue number reindexed from 1)		N156 H157
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.9: UTP--glucose-1-phosphate uridylyltransferase.
Gene Ontology
Molecular Function
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0016779 nucleotidyltransferase activity
GO:0032557 pyrimidine ribonucleotide binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051748 UTP-monosaccharide-1-phosphate uridylyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006011 UDP-glucose metabolic process
GO:0006065 UDP-glucuronate biosynthetic process
GO:0007420 brain development
GO:0019255 glucose 1-phosphate metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4r7p, PDBe:4r7p, PDBj:4r7p
PDBsum4r7p
PubMed25860585
UniProtQ16851|UGPA_HUMAN UTP--glucose-1-phosphate uridylyltransferase (Gene Name=UGP2)

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