Structure of PDB 4qkf Chain B Binding Site BS01

Receptor Information

>4qkf Chain B (length=190) Species: 9606 (Homo sapiens)

MWVRGSGPSVLSRLQDAAVVRPGFLSTAEEETLSRELEPELRRRRYEYDH
WDAAIHGFRETEKSRWSEASRAILRRVQAAAFGPQTLLSSVHVLDLEARG
YIKPHVDSIKFCGATIAGLSLLSPSVMRLVHTQEPGEWLELLLEPGSLYI
LRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLP

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4qkf Chain B Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4qkf The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism
• Resolution: 1.99 Å
• Binding residue (original residue number in PDB): H121 D123 H177
• Binding residue (residue number reindexed from 1): H105 D107 H161
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 1.14.11.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0006631 fatty acid metabolic process
• GO:0006974 DNA damage response
• GO:0010883 regulation of lipid storage
• GO:0012501 programmed cell death
• GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:4qkf, PDBe:4qkf, PDBj:4qkf
• PDBsum: 4qkf
• PubMed: 25122757
• UniProt: Q9BT30|ALKB7_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (Gene Name=ALKBH7)