Structure of PDB 4qj9 Chain B Binding Site BS01

Receptor Information
>4qj9 Chain B (length=99) Species: 11685 (HIV-1 M:B_ARV2/SF2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGI
GGFIKVRQYDQIPIEICGHKVIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Ligand information
Receptor-Ligand Complex Structure
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PDB4qj9 Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
Resolution1.83 Å
Binding residue
(original residue number in PDB)		R8 N25 G27 A28 D29 D30 M46 I47 G48 V82
Binding residue
(residue number reindexed from 1)		R8 N25 G27 A28 D29 D30 M46 I47 G48 V82
Enzymatic activity
Catalytic site (original residue number in PDB) N25 T26 G27
Catalytic site (residue number reindexed from 1) N25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4qj9, PDBe:4qj9, PDBj:4qj9
PDBsum4qj9
PubMed25355911
UniProtP03369|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

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