Structure of PDB 4qiw Chain B Binding Site BS01

Receptor Information
>4qiw Chain B (length=1069) Species: 69014 (Thermococcus kodakarensis KOD1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTLTPDELWLVMESYWKEKGFVRQHLDSYNAFIDHGLQDVVNEFGEVVPD
IPNFKVKFGKIRIGQPEFQEAQGQRRPLYPMDARIRNLTYSAPLYLEMIP
VVNGIEQEPVEVRIGELPIMLKSKACRLYGLSDEELIKLGEDPKDPGGYF
IINGSERVIVSIEDLAPNKTLVERDERQNKVVAKVFSYRHGYRALITVER
KKDGILYVTIPNVPKPVKFVYVMRALGLLTDKEIVEAVSDDPRIQQVLFD
NLEDASDISTQEEALDYIGRLALPGQPKEYRLRRAEHIIDNNLLPHMGVD
PENRRAKAYYLGMMALKVLELSLGLRGEDDKDHYANKRLKLAGDLLKDLF
RVAFGQLVKDMQYQMTKTYQRENIQRFVRNSIRPDVLSERIEHALATGSW
PGGRTGVSQLLDRTNYMSTLSHLRRVTSPLSRDQPHFEARDLHGTHWGRI
CPTETPEGPNCGLVKNLALMSQITTGIPEREVREYLMKMGVVPIEERRPA
PGLYRVYLNGVLIGTVEDGRKLVERIRADRRAGKISDVINVALYEDEEVK
EVYINSDDGRVRRPLIVVENGKPKLTREHVEGIKNGTLTWSDLIRMGVIE
YLDAEEEENAYVATWPWEVTEEHTHLELMPAAILGIPASLVPYPEHNAAP
RNTYGAGMAKQSLGLGWANFRIRVDTRGHLMHYPQVPLVNSRIMKAVGFE
DRPAGQNFVVAVLSYHGYNMEDAVIINKASIERGLARSTFFRTYEAEEKR
YLGGQKDNFEVPSPNIQGYLGEKYYRHLDEDGLIFPESKVEGKDVLVGRT
SPPRRRETSVTVRPSEKGVVDKVIVTETGDGTKLVKVTVRDLRIPELGDK
FASRHGQKGVIGLIVPQEDMPWTESGIVPDLIVNPHGIPSRMTVGQLIEA
IGGKVASLTGRRVDGTAFIGEPEEKLRKELEELGFKHSGREIMYDGITGR
RLEADIFIGVIYYQRLHHMVADKMHARSFGEMERDVLIGHGAAMLLIERL
LEESDKTEVWVCESCGHLALEDKRRGKVYCPVCGEDERISKVEMSYAFKL
LLDELKAMVIRPSLRLKDR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4qiw Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4qiw The X-ray crystal structure of the euryarchaeal RNA polymerase in an open-clamp configuration.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		C1065 C1068 C1083
Binding residue
(residue number reindexed from 1)		C1012 C1015 C1030
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qiw, PDBe:4qiw, PDBj:4qiw
PDBsum4qiw
PubMed25311937
UniProtQ5JE32

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