Structure of PDB 4qil Chain B Binding Site BS01
Receptor Information
>4qil Chain B (length=292) Species:
9606
(Homo sapiens) [
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DTKHYEEAKKCVEELALYLKVLSRPMQRKLVTLVHCQLVEEEGRIRAMRA
ARSLGERTVTELILQHQNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLV
LLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKV
TKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLL
YGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHL
ELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHS
Ligand information
>4qil Chain D (length=16) [
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ucccuucugugaaggg
.<<<<<<...>>>>>>
Receptor-Ligand Complex Structure
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PDB
4qil
The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
W184 F194 R219 K220 S238 K239 T240 Q247 Y250 R251 S253 E262 D263 S264
Binding residue
(residue number reindexed from 1)
W77 F87 R112 K113 S131 K132 T133 Q140 Y143 R144 S146 E155 D156 S157
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4qil
,
PDBe:4qil
,
PDBj:4qil
PDBsum
4qil
PubMed
25026078
UniProt
Q5TC82
|RC3H1_HUMAN Roquin-1 (Gene Name=RC3H1)
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