Structure of PDB 4qi2 Chain B Binding Site BS01
Receptor Information
>4qi2 Chain B (length=153) Species:
10090
(Mus musculus) [
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HQNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVL
VLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEE
FRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIID
KLQ
Ligand information
>4qi2 Chain F (length=18) [
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uguuuucugugaaaacgg
<<<<<<<...>>>>>>>.
Receptor-Ligand Complex Structure
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PDB
4qi2
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
R188 R219 K220 S238 K239 T240 Q247 Y250 R251 E262 D263 S264 S265
Binding residue
(residue number reindexed from 1)
R16 R47 K48 S66 K67 T68 Q75 Y78 R79 E90 D91 S92 S93
Binding affinity
PDBbind-CN
: Kd=119nM
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4qi2
,
PDBe:4qi2
,
PDBj:4qi2
PDBsum
4qi2
PubMed
25026077
UniProt
Q4VGL6
|RC3H1_MOUSE Roquin-1 (Gene Name=Rc3h1)
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