Structure of PDB 4q3u Chain B Binding Site BS01

Receptor Information

>4q3u Chain B (length=335) Species: 6183 (Schistosoma mansoni)

PKLLYTSANFLGIPTNRGQPKIGTYQGPELIRKSNFFQLVAEDGIQLTDC
GDIIPVELNEAEDPQRFGMKWSRSFSLTTLRIAERVEELMKQSSTPLVIV
GGDHSMATGTILGHAEAKPDLCVLWIDAHGDINTPLNSASGNMHGMPLSF
LVKELQDQIPWLDDFEGIKPCLNASNIAYIGLRDLDAHETHDIRKHGIAY
FTMLDVDRMGIEAVIKEALLAVNPRLEKAIHLSFDIDALDPLVAPSTGTA
VPGGLTLREGLRICEEVSATGKLSVVELAELNPLLGSQEDVLKTQSSAVH
ILRACLGHCRSGHLPFKVRNLTDQGIMSRAAHMQT

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4q3u Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4q3u Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): H131 D154 D158 D262
• Binding residue (residue number reindexed from 1): H104 D127 D131 D235
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H131 D154 H156 D158 H171 D262 D264 E307
• Catalytic site (residue number reindexed from 1): H104 D127 H129 D131 H144 D235 D237 E280
• Enzyme Commision number: 3.5.3.1: arginase.

Gene Ontology

Molecular Function

• GO:0004053 arginase activity
• GO:0016787 hydrolase activity
• GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000050 urea cycle
• GO:0006525 arginine metabolic process
• GO:0019547 arginine catabolic process to ornithine

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4q3u, PDBe:4q3u, PDBj:4q3u
• PDBsum: 4q3u
• PubMed: 25007099
• UniProt: Q6WVP6