Structure of PDB 4pxm Chain B Binding Site BS01
Receptor Information
>4pxm Chain B (length=226) Species:
9606
(Homo sapiens) [
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SLALSLTADQMVSALLDAEPPILYSESEASMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTK
DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM
EHLYSMKCKNVVPLYGLLLEMLDAHR
Ligand information
>4pxm Chain D (length=7) Species:
9606
(Homo sapiens) [
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ILHRLLQ
Receptor-Ligand Complex Structure
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PDB
4pxm
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
I358 K362 G538 E542
Binding residue
(residue number reindexed from 1)
I47 K51 G216 E220
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4pxm
,
PDBe:4pxm
,
PDBj:4pxm
PDBsum
4pxm
PubMed
26836308
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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