Structure of PDB 4pl8 Chain B Binding Site BS01

Receptor Information
>4pl8 Chain B (length=345) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRSYVGDEALTLKYPIEHGI
ITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFE
TFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAI
MRLDLAGRDLTDYLMKILTERGYSFEREIVRDIKEKLCYVALDFENEMAT
AASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTY
NSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKI
IAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC
Ligand information
>4pl8 Chain H (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MAEIPDMAEIEKFDKSKLKKTETQEK
Receptor-Ligand Complex Structure
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PDB4pl8 Structural basis of thymosin-beta 4/profilin exchange leading to actin filament polymerization.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		T148 E167 L349 S350
Binding residue
(residue number reindexed from 1)		T123 E142 L320 S321
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003785 actin monomer binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005523 tropomyosin binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0031013 troponin I binding
GO:0031432 titin binding
GO:0032036 myosin heavy chain binding
GO:0042802 identical protein binding
GO:0048306 calcium-dependent protein binding
GO:0140660 cytoskeletal motor activator activity
Biological Process
GO:0010628 positive regulation of gene expression
GO:0030041 actin filament polymerization
GO:0030240 skeletal muscle thin filament assembly
GO:0048741 skeletal muscle fiber development
GO:0051017 actin filament bundle assembly
GO:0090131 mesenchyme migration
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031941 filamentous actin
GO:0032432 actin filament bundle
GO:0044297 cell body
GO:0098723 skeletal muscle myofibril

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4pl8, PDBe:4pl8, PDBj:4pl8
PDBsum4pl8
PubMed25313062
UniProtP68135|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)

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