Structure of PDB 4p0q Chain B Binding Site BS01

Receptor Information
>4p0q Chain B (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAALVTRMKAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVI
EAQAVPCSVTWRRRAGPSEDREDWVEEPTVLVLLRAEAFVSMIDNGKTLQ
GFVTDITAKTAGKALSLVIVDQEKCFVSRVDAEEALVDLQLHTEAQAQIV
QSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGR
GLALVWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNL
LADIQVRRTSRRIGPELSRRIYLQMTTLQPHLSL
Ligand information
Receptor-Ligand Complex Structure
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PDB4p0q Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.
Resolution2.851 Å
Binding residue
(original residue number in PDB)		K441 E445 K449 R452
Binding residue
(residue number reindexed from 1)		K165 E169 K173 R176
Enzymatic activity
Enzyme Commision number 3.1.22.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
Biological Process
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
GO:0048476 Holliday junction resolvase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4p0q, PDBe:4p0q, PDBj:4p0q
PDBsum4p0q
PubMed24733841
UniProtQ96AY2|EME1_HUMAN Crossover junction endonuclease EME1 (Gene Name=EME1)

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