Structure of PDB 4o26 Chain B Binding Site BS01

Receptor Information
>4o26 Chain B (length=228) Species: 8090 (Oryzias latipes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGFLYGGRGMHGFCLNRKRRTAAGPRRLQGQDLVRLVFFEKKLPLRYFNM
VPVFGRLLQRHRKCRYSSVLHRMCPVVELSRAAQGELSSLIPQHCAPHRV
YLFVRECLTAVVPEELWGSDHNRLQFFSRVRGFLKSGKFERISVELMWKI
KVMDCDWLKLPPSELAYRTRILSQFLTWLLDGFVVGLVRACFYATESVGQ
KNAIRFYRQEVWSKLQDLAFRRHIAKGE
Ligand information
>4o26 Chain F (length=47) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggaacgccgcggucagcucggcugcugcgaagagucucuguuguucc
<<<<...<<<<<.<<<<...>>>>>>>>>.<<<<.>>>>....>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4o26 Structural basis for protein-RNA recognition in telomerase.
Resolution3.001 Å
Binding residue
(original residue number in PDB)		K370 L371 P372 L373 R374 F376 K478 I479 K480 V481 M482 L489 P497 P498 S499 Y503 R506
Binding residue
(residue number reindexed from 1)		K42 L43 P44 L45 R46 F48 K149 I150 K151 V152 M153 L160 P161 P162 S163 Y167 R170
Binding affinityPDBbind-CN: Kd=0.76uM
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003964 RNA-directed DNA polymerase activity

View graph for
Molecular Function
External links
PDB RCSB:4o26, PDBe:4o26, PDBj:4o26
PDBsum4o26
PubMed24793650
UniProtQ1PS67|TERT_ORYLA Telomerase reverse transcriptase (Gene Name=tert)

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