Structure of PDB 4nv0 Chain B Binding Site BS01

Receptor Information

>4nv0 Chain B (length=300) Species: 7227 (Drosophila melanogaster)

RLRLQDIPALTQDHCRMRDPAEVERIINEFVIGGPERMQIVSDFDYTITK
QRTEDGGAVPSSFGIFNACQSLPENFKAETDKLYHKYRPIEIDPHMPIAE
KVQYMIEWWTKSGELTSGFPFDQSEIDQIASKYTHALRDRTHEFFADLQR
LGIPTLVFSAGLGNSVVSVLRQANVLHPNVKVVSNFLQFRDGLLDGFQQP
MIHTFNKNETVLNETSEYYDLVHTRDHIIVMGDSIGDADMASGVPASSHI
MKIGFLFDHVEANMKKYMDTFDIVLVDDQTMDVPRTLLSLIEKQHKLNLE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4nv0 Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4nv0 Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP
• Resolution: 1.65 Å
• Binding residue (original residue number in PDB): D55 D57 D245
• Binding residue (residue number reindexed from 1): D43 D45 D233
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.5: 5'-nucleotidase.
  3.1.3.91: 7-methylguanosine nucleotidase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0008252 nucleotidase activity
• GO:0008253 5'-nucleotidase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding
• GO:0106411 XMP 5'-nucleosidase activity

Biological Process

• GO:0009117 nucleotide metabolic process
• GO:0009158 ribonucleoside monophosphate catabolic process
• GO:1901069 guanosine-containing compound catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4nv0, PDBe:4nv0, PDBj:4nv0
• PDBsum: 4nv0
• PubMed: 24603684
• UniProt: Q9W197|5NT3B_DROME 7-methylguanosine phosphate-specific 5'-nucleotidase (Gene Name=cN-IIIB)