Structure of PDB 4nnd Chain B Binding Site BS01

Receptor Information

>4nnd Chain B (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DSARSFLERLEARVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNR
YKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHT
LLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITL
IKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMV
EEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLF
DVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS

Ligand information

>4nnd Chain C (length=6) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

LQRYSE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4nnd Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Resolution	2.502 Å
Binding residue (original residue number in PDB)	Y62 D64 D197 S229 S230 A231 C233 R235 Q276
Binding residue (residue number reindexed from 1)	Y51 D53 D186 S218 S219 A220 C222 R224 Q265

Enzymatic activity

Enzyme Commision number

3.1.3.48: protein-tyrosine-phosphatase.

Gene Ontology

	Molecular Function
GO:0004725	protein tyrosine phosphatase activity
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity

	Biological Process
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:4nnd, PDBe:4nnd, PDBj:4nnd
PDBsum	4nnd
PubMed
UniProt	Q99952\|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

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