Structure of PDB 4nib Chain B Binding Site BS01

Receptor Information
>4nib Chain B (length=30) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVNQHLCGSHLVEALYLVCAERAFFYTPKT
Ligand information
>4nib Chain A (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4nib Protective hinge in insulin opens to enable its receptor engagement.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		V2 N3 Q4 H5 L6 C7 L11 L15 V18 C19 R22 A23 F24 F25 P28
Binding residue
(residue number reindexed from 1)		V2 N3 Q4 H5 L6 C7 L11 L15 V18 C19 R22 A23 F24 F25 P28
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005179 hormone activity
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4nib, PDBe:4nib, PDBj:4nib
PDBsum4nib
PubMed25092300
UniProtP01308|INS_HUMAN Insulin (Gene Name=INS)

[Back to BioLiP]