Structure of PDB 4ndg Chain B Binding Site BS01

Receptor Information
>4ndg Chain B (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISSL
KAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLHV
ISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPELL
KLPLRCHECQQLLPSIPQLKEHLRKHW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ndg Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Resolution2.541 Å
Binding residue
(original residue number in PDB)		W167 Y195 K197 H251 S255 H278
Binding residue
(residue number reindexed from 1)		W4 Y32 K34 H88 S92 H115
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4ndg, PDBe:4ndg, PDBj:4ndg
PDBsum4ndg
PubMed24362567
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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