Structure of PDB 4nca Chain B Binding Site BS01 |
| >4nca Chain B (length=678) Species: 274 (Thermus thermophilus)
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LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVL
DLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE
LLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKKPIPH
LTGLLVPVLTLEDLHEEGSLALSLPWEERRRRTREIASWIGRRLGLGTPE
AVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGW
PEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVL
VLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAK
AGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPE
AQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALA
LEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVH
RDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLH
LADRLVKEVGRLGIRHLKEVDREKLFFV |
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| PDB | 4nca Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. |
| Resolution | 2.489 Å |
Binding residue
(original residue number in PDB) | Y43 R59 A170 Y171 R172 I173 R192 T201 V264 L265 T266 L267 L279 L281 R286 M413 W415 R418 K422 Q433 I434 N436 H445 R446 N449 K457 R486 E512 R513 P550 R580 R611 T613 P614 R615 A644 S645 A648 P650 R651 H657 R661 V685 |
Binding residue
(residue number reindexed from 1) | Y40 R56 A167 Y168 R169 I170 R189 T198 V258 L259 T260 L261 L272 L274 R279 M406 W408 R411 K415 Q426 I427 N429 H438 R439 N442 K450 R479 E505 R506 P543 R573 R604 T606 P607 R608 A637 S638 A641 P643 R644 H650 R654 V678 |
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