Structure of PDB 4mrc Chain B Binding Site BS01

Receptor Information

>4mrc Chain B (length=114) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSEPGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDGPRRYTIAAL
LSPYSYSTTAVVTN

Ligand information

InChI=1S/Ca/q+2

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Ca

Name

CALCIUM ION

PDB chain

4mrc Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	4mrc Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.
Resolution	1.54 Å
Binding residue (original residue number in PDB)	E66 N98
Binding residue (residue number reindexed from 1)	E57 N89
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0070324	thyroid hormone binding

	Biological Process
GO:0006144	purine nucleobase metabolic process
GO:0007165	signal transduction

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0035578	azurophil granule lumen
GO:0070062	extracellular exosome

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Cellular Component

External links

PDB	RCSB:4mrc, PDBe:4mrc, PDBj:4mrc
PDBsum	4mrc
PubMed	24474780
UniProt	P02766\|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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