Structure of PDB 4m1z Chain B Binding Site BS01

Receptor Information

>4m1z Chain B (length=315) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

ADRPWANDYLRIQEAQKFATGAGVTVAVIDTGVNGSPRVPAEPGGDFVDA
AGNGMSDCDAHGTMTAAIIGGRPSPTDGFVGMAPDVRLLSLRQTSVTAGS
IRSLARSVVHAANLGAQVINISEAACYKVTRRIDETSLGAAINYAVNVKG
AVIVVAAGNTGQDCSQNPPPDPSVPSDPRGWREVQTIVSPAWYDPLVLTV
GSIGQNGQPSNFSMSGPWVGAAAPGENLTSLGYDGQPVNATPGEDGPVPL
NGTSFSAAYVSGLAALVKQRFPDLTPAQIINRITATARHPGGGVDNYVGA
GVIDPVAALTWEIPD

Ligand information

>4m1z Chain D (length=13) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

RVKEVPPPVYIPP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4m1z The putative propeptide of MycP1 in mycobacterial type VII secretion system does not inhibit protease activity but improves protein stability.
• Resolution: 2.25 Å
• Binding residue (original residue number in PDB): C120 D121 A122 M126 Y313 V318 N319 A320 P322 P327
• Binding residue (residue number reindexed from 1): C58 D59 A60 M64 Y233 V238 N239 A240 P242 P247

Enzymatic activity

• Catalytic site (original residue number in PDB): D92 H123 N239 S334
• Catalytic site (residue number reindexed from 1): D30 H61 N159 S254
• Enzyme Commision number: 3.4.21.-

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:4m1z, PDBe:4m1z, PDBj:4m1z
• PDBsum: 4m1z
• PubMed: 24248472
• UniProt: A0QNL1|MYCP1_MYCS2 Mycosin-1 (Gene Name=mycP1)