Structure of PDB 4luq Chain B Binding Site BS01

Receptor Information

>4luq Chain B (length=409) Species: 208964 (Pseudomonas aeruginosa PAO1)

HMTATSDLIESLISYSWDDWQVTRQEARRVIAAIRNDNVPDATIAALDKS
GSLIKLFQRVGPPELARSLIASIAGRTTMQRYQARNALIRSLINNPLGTQ
TDNWIYFPTITFFDICADLADAAGRLGFAAAGATGVASQAIQGPFSGVGA
TGVNPTDLPSIAFGDQLKLLNKDPATVTKYSNPLGDLGAYLSQLSPQDKL
NQAQTLVGQPISTLFPDAYPGNPPSRAKVMSAAARKYDLTPQLIGAIILA
EQRDQTRDEDAKDYQAAVSIKSANTSIGLGQVVVSTAIKYELFTDLLGQP
VRRGLSRKAVATLLASDEFNIFATARYIRYVANLASQQDLRKLPKTRGAF
PSIDLRAYAGNPRNWPRDNVRALASEYTSRPWDDNLSPGWPMFVDDAYAT
FLDPGMRFP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4luq Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4luq Structural Insights on the Bacteriolytic and Self-protection Mechanism of Muramidase Effector Tse3 in Pseudomonas aeruginosa
• Resolution: 1.77 Å
• Binding residue (original residue number in PDB): E375 S378 R379 D382 N384
• Binding residue (residue number reindexed from 1): E376 S379 R380 D383 N385
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005576 extracellular region
• GO:0016020 membrane
• GO:0033644 host cell membrane

External links

• PDB: RCSB:4luq, PDBe:4luq, PDBj:4luq
• PDBsum: 4luq
• PubMed: 24025333
• UniProt: Q9HYC5|TSE3_PSEAE Peptidoglycan muramidase Tse3 (Gene Name=tse3)