Structure of PDB 4lt6 Chain B Binding Site BS01

Receptor Information
>4lt6 Chain B (length=462) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKL
NNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALC
VAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDL
VFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKE
TFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTL
VHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITP
AYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFF
QKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNP
QSFPGNYVSMWFLGIIFRDLTYDIQSFTDTVYRQANNINMLKEGMKIEAT
HVKKKQLHHYLP
Ligand information
Ligand ID3AT
InChIInChI=1S/C10H16N5O12P3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,10+/m0/s1
InChIKeyNLIHPCYXRYQPSD-BAJZRUMYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)C[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3
OpenEye OEToolkits 1.7.5c1nc(c2c(n1)n(cn2)[C@H]3[C@@H](C[C@H](O3)CO[P@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)N
CACTVS 3.385Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)C[C@H]3O
OpenEye OEToolkits 1.7.5c1nc(c2c(n1)n(cn2)C3C(CC(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)N
FormulaC10 H16 N5 O12 P3
Name3'-DEOXYADENOSINE-5'-TRIPHOSPHATE;
CORDYCEPIN TRIPHOSPHATE
ChEMBLCHEMBL480329
DrugBankDB01860
ZINCZINC000013540909
PDB chain4lt6 Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4lt6 Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		F99 S101 D114 Y236 V246 T316 S324
Binding residue
(residue number reindexed from 1)		F82 S84 D97 Y219 V229 T299 S307
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) S101 D112 D114 D166 K227 Y236
Catalytic site (residue number reindexed from 1) S84 D95 D97 D149 K210 Y219
Enzyme Commision number 2.7.7.19: polynucleotide adenylyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016779 nucleotidyltransferase activity
GO:1990817 poly(A) RNA polymerase activity
Biological Process
GO:0031123 RNA 3'-end processing
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lt6, PDBe:4lt6, PDBj:4lt6
PDBsum4lt6
PubMed24076191
UniProtQ9BWT3|PAPOG_HUMAN Poly(A) polymerase gamma (Gene Name=PAPOLG)

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