Structure of PDB 4l9o Chain B Binding Site BS01

Receptor Information
>4l9o Chain B (length=311) Species: 4922,644223 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQFPIFHWCRGGKALSMLPKFKVEINIVGGSVTIGNAHDDLIHDAVLDYY
GRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVIL
ASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCAS
SDGKISIVEFGALEPIVIQGHAIGVNAASWAPISNTRRFVSGGCDNLVKI
WRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW
TKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKEN
IQGKWESAGEV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4l9o Chain B Residue 2401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4l9o Sec16 influences transitional ER sites by regulating rather than organizing COPII.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		S2132 I2157
Binding residue
(residue number reindexed from 1)		S151 I173
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
Biological Process
GO:0006606 protein import into nucleus
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032008 positive regulation of TOR signaling
GO:0032527 protein exit from endoplasmic reticulum
GO:0036503 ERAD pathway
GO:0045893 positive regulation of DNA-templated transcription
GO:0051028 mRNA transport
GO:0051664 nuclear pore localization
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:0090114 COPII-coated vesicle budding
GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
GO:1903432 regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030127 COPII vesicle coat
GO:0031080 nuclear pore outer ring
GO:0031410 cytoplasmic vesicle
GO:0035859 Seh1-associated complex
GO:0061700 GATOR2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l9o, PDBe:4l9o, PDBj:4l9o
PDBsum4l9o
PubMed24006484
UniProtP53024;
Q45TY0

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