Structure of PDB 4l3o Chain B Binding Site BS01

Receptor Information
>4l3o Chain B (length=295) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSLEKYH
LPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLL
LRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKE
KIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMG
TSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDS
KKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4l3o Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change
Resolution2.518 Å
Binding residue
(original residue number in PDB)		E116 E120 H187 V233 F235 G236 E237 S238 L239 F244 Q265 V266 Q267 P268 S271 S293 D294 F296 G298 M299 M301
Binding residue
(residue number reindexed from 1)		E55 E59 H126 V172 F174 G175 E176 S177 L178 F183 Q204 V205 Q206 P207 S210 S232 D233 F235 G237 M238 M240
Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P39 D40 F41 R42 N107 D109 H126
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4l3o, PDBe:4l3o, PDBj:4l3o
PDBsum4l3o
PubMed24389023
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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