Structure of PDB 4kr9 Chain B Binding Site BS01

Receptor Information
>4kr9 Chain B (length=386) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRVYIVRYSEIGLKGKNRKDFEEALRRNIERVTGMKVKRQWGRFLIPID
ENVTLDDKLKKIFGIQNFSKGFLVSHDFEEVKKYSLIAVKEKLEKGNYRT
FKVQAKKAYKEYKKGVYEINSELGALILKNFKELSVDVRNPDFVLGVEVR
PEGVLIFTDRVECYGGLPVGTGGKAVLLLSGGIDSPVAGWYALKRGVLIE
SVTFVSPPFTSEGAVEKVRDILRVLREFSGGHPLRLHIVNLTKLQLEVKK
RVPDKYSLIMYRRSMFRIAEKIAEETGAVAFYTGENIGQVASQTLENLWS
IESVTTRPVIRPLSGFDKTEIVEKAKEIGTYEISIKPYQDSCVFFAPKNP
ATRSHPSILEKLEQQVPDLPVLEEEAFTSRKVEVIE
Ligand information
>4kr9 Chain M (length=39) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggauaguguccuugggaaaccaaguccgggcacca
<<<<<<<<.......<<<<....>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB4kr9 Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K338 N351
Binding residue
(residue number reindexed from 1)		K336 N349
Enzymatic activity
Enzyme Commision number 2.8.1.4: tRNA uracil 4-sulfurtransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0004810 CCA tRNA nucleotidyltransferase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity
GO:0140741 tRNA-uracil-4 sulfurtransferase activity
Biological Process
GO:0002937 tRNA 4-thiouridine biosynthesis
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0034227 tRNA thio-modification
GO:0052837 thiazole biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kr9, PDBe:4kr9, PDBj:4kr9
PDBsum4kr9
PubMed24705700
UniProtQ9X220|THII_THEMA Probable tRNA sulfurtransferase (Gene Name=thiI)

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