Structure of PDB 4kpy Chain B Binding Site BS01 |
| >4kpy Chain B (length=675) Species: 262724 (Thermus thermophilus HB27)
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HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPGGLSLLDYHASKGRLQGREGGRVAWVADPKPIPHLT
GLLVPVLTLEDLHEEELALSLPWEERRRRTREIASWIGRRLGLGTPEAVR
AQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEF
LRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLT
PPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGL
QVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQA
GERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEA
LAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDF
RGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLAD
RLVKEVGRLGIRHLKEVDREKLFFV |
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| PDB | 4kpy Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. |
| Resolution | 2.406 Å |
Binding residue
(original residue number in PDB) | Y43 A170 Y171 R172 I173 R192 T201 V264 L265 L279 S280 L281 R286 M413 W415 K422 Q433 I434 N436 R446 N449 K457 R486 E512 R513 R580 R611 G612 T613 P614 R615 S645 A648 P650 R651 H657 R661 V685 |
Binding residue
(residue number reindexed from 1) | Y41 A168 Y169 R170 I171 R190 T199 V256 L257 L269 S270 L271 R276 M403 W405 K412 Q423 I424 N426 R436 N439 K447 R476 E502 R503 R570 R601 G602 T603 P604 R605 S635 A638 P640 R641 H647 R651 V675 |
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