Structure of PDB 4kkm Chain B Binding Site BS01

Receptor Information

>4kkm Chain B (length=280) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821)

MAVNLKTMMEQVAQDIDRLFAEQLPVPEDPRRRLVEAMRYAAIGGGKRLR
PLLVVATCALFNVDREAALRVGMAIECIHVYSLIHDDMPCMDNDDLRRGK
PTVHKAFDDASAVLSGDALQALAFEILSEEKIHTDPHVRLELIQALAIAS
GKDGMVGGQAIDLAAETSTVPFDLPTITRLQQLKTGALFGFCLEAGAIMG
RQNKDIRDRLKAYARDIGLAFQIADDLIDAEGDGKATFLSLLGLEKARSQ
AQALVDQAIAHLSVFGSEADYLRSIARYIV

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4kkm Chain B Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4kkm Crystal structure of a FPP/GFPP synthase (Target EFI-501952) from Zymomonas mobilis, apo structure
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D86 D92
• Binding residue (residue number reindexed from 1): D86 D92
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): K47 Y81 D86 D92 R97 D162 K184 F221 D225 D226
• Catalytic site (residue number reindexed from 1): K47 Y81 D86 D92 R97 D162 K184 F221 D225 D226
• Enzyme Commision number: 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.

Gene Ontology

Molecular Function

• GO:0004659 prenyltransferase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008299 isoprenoid biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4kkm, PDBe:4kkm, PDBj:4kkm
• PDBsum: 4kkm
• UniProt: Q5NP81