Structure of PDB 4k96 Chain B Binding Site BS01
Receptor Information
>4k96 Chain B (length=358) Species:
10090
(Mus musculus) [
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SPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKPRGNP
LSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLL
IRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYL
VPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKEC
LKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSS
CFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYER
NNGFPIFD
Ligand information
>4k96 Chain E (length=17) [
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aaattgccgaagacgaa
Receptor-Ligand Complex Structure
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PDB
4k96
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Resolution
2.084 Å
Binding residue
(original residue number in PDB)
T334 K335 T338 R342
Binding residue
(residue number reindexed from 1)
T187 K188 T191 R195
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4k96
,
PDBe:4k96
,
PDBj:4k96
PDBsum
4k96
PubMed
23647843
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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