Structure of PDB 4js5 Chain B Binding Site BS01

Receptor Information
>4js5 Chain B (length=464) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDY
LPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRF
DDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPEN
DDGLPSFRLEHLTKANGIEHSNAHDAMADVYATIAMAKLVKTRQPRLFDY
LFTHRNKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRN
AVIMVDLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCP
VLAQANTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAPSD
NVDAQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYR
ARNFPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKV
ALLKALWQYAEEIV
Ligand information
Receptor-Ligand Complex Structure
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PDB4js5 Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		E17 T18 T21 T67 Y102 N103 F107 R113 Y124 W128 F164 H181 G234 M235 G237 A238 N255 N257 L283 Y284 A286 K287 N304 F371
Binding residue
(residue number reindexed from 1)		E10 T11 T14 T60 Y95 N96 F100 R106 Y117 W121 F157 H174 G227 M228 G230 A231 N248 N250 L276 Y277 A279 K280 N297 F360
Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006274 DNA replication termination
GO:0006281 DNA repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4js5, PDBe:4js5, PDBj:4js5
PDBsum4js5
PubMed23609540
UniProtP04995|EX1_ECOLI Exodeoxyribonuclease I (Gene Name=sbcB)

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