Structure of PDB 4inh Chain B Binding Site BS01

Receptor Information
>4inh Chain B (length=170) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDDKAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSS
IAIHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLP
LAVRMGAIASMRIQGRLVHGQSGMLLTGGTIPGDCGAPYVHKRGNDWVVC
GVHAAATKSGNTVVCAVQAG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4inh Structural basis of substrate specificity and protease inhibition in norwalk virus.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H30 I109 Q110 T134 P136 C139 A158 A159 A160 T161 K162 V168
Binding residue
(residue number reindexed from 1)		H34 I113 Q114 T130 P132 C135 A154 A155 A156 T157 K158 V164
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4inh, PDBe:4inh, PDBj:4inh
PDBsum4inh
PubMed23365454
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

[Back to BioLiP]