Structure of PDB 4il3 Chain B Binding Site BS01

Receptor Information

>4il3 Chain B (length=431) Species: 114525 (Saccharomyces mikatae)

PTIPWKLIISAFSIAQFSFESYLTYRQYQKLSETKLPPVLEDEIDDETFH
KSRNYSRAKAKFSIFSDIYNLAQKLVFIKYDFFPKIWHMAVTLPVRFHMV
STVAQSLCFLGLLSSMSTLVDLPLSYYSHFVLEEKFGFNKLTVKLWITDM
IKSLTLAYAIGGPILYLFLKIFDKFPTDFLWYIMVFLFVVQILAMTIIPV
FIMPLFNKFTPLEDGELKKSIESLADRVGFPLDKIFVIDGSKRSSHSNAY
FTGLPFTSKRIVLFDTLVNSNSTDEITAVLAHEIGHWQKNHIVNMVIFSQ
LHTFLIFSLFTSIYRNSSFYNTFGFFVEKSSSGFVDPVITKEFPIIIGFM
LFNDLLTPLECAMQFIMSLISRTHEYQADAYAKKLGYKQNLCRALIDLQI
KNLSTMNVDPLYSSYHYSHPTLAERLTALDY

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4il3 Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4il3 Structure of the integral membrane protein CAAX protease Ste24p.
• Resolution: 3.102 Å
• Binding residue (original residue number in PDB): H297 H301 E390
• Binding residue (residue number reindexed from 1): H282 H286 E375
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.24.84: Ste24 endopeptidase.

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004222 metalloendopeptidase activity
• GO:0008233 peptidase activity
• GO:0008237 metallopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0071586 CAAX-box protein processing

Cellular Component

• GO:0005783 endoplasmic reticulum
• GO:0005789 endoplasmic reticulum membrane
• GO:0016020 membrane

External links

• PDB: RCSB:4il3, PDBe:4il3, PDBj:4il3
• PDBsum: 4il3
• PubMed: 23539602
• UniProt: M4GGS2