Structure of PDB 4igk Chain B Binding Site BS01

Receptor Information
>4igk Chain B (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEF
VCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRN
HQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKEL
SSFTLGTGVHPIVVVQPDAWNGFHAIGQMCEAPVVTREWVLDSVALYQCQ
ELDTYLIPQIP
Ligand information
Receptor-Ligand Complex Structure
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PDB4igk Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		S1655 E1698 R1699 K1702 V1741 N1774 M1775
Binding residue
(residue number reindexed from 1)		S10 E53 R54 K57 V96 N129 M130
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4igk, PDBe:4igk, PDBj:4igk
PDBsum4igk
PubMed24073851
UniProtP38398|BRCA1_HUMAN Breast cancer type 1 susceptibility protein (Gene Name=BRCA1)

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