Structure of PDB 4i32 Chain B Binding Site BS01

Receptor Information

>4i32 Chain B (length=182) Species: 11116 (Hepatitis C virus (isolate Japanese))

APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHV
VGIFRAAVCTRGVAKAVVFIPVESMETTMRAS

Ligand information

>4i32 Chain D (length=13) Species: 11116 (Hepatitis C virus (isolate Japanese))

KGSVVIVGRIILS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4i32 Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance.
• Resolution: 2.3001 Å
• Binding residue (original residue number in PDB): I3 T4 A5 Y6 S7 Q8 T10 R11 S20 D30 E32 V33 V35 L36 S37 K62 T63 L64 A65 R92 R109
• Binding residue (residue number reindexed from 1): I3 T4 A5 Y6 S7 Q8 T10 R11 S20 D30 E32 V33 V35 L36 S37 K62 T63 L64 A65 R92 R109

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D81 G137 S139
• Catalytic site (residue number reindexed from 1): H57 D81 G137 S139
• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.21.98: hepacivirin.
  3.4.22.-
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019087 transformation of host cell by virus

External links

• PDB: RCSB:4i32, PDBe:4i32, PDBj:4i32
• PDBsum: 4i32
• PubMed: 23271737
• UniProt: P26662|POLG_HCVJA Genome polyprotein