Structure of PDB 4i21 Chain B Binding Site BS01

Receptor Information

>4i21 Chain B (length=302) Species: 9606 (Homo sapiens)

LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS
PKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYV
REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK
ITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV
TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWM
IDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTVVDADEYLI
PQ

Ligand information

>4i21 Chain D (length=26) Species: 9606 (Homo sapiens)

SLPSYLNGVMPPTQSFAPDPKYVSSK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4i21 Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
• Resolution: 3.37 Å
• Binding residue (original residue number in PDB): Y915 E928 G930 E931 R932 P934 Q935 P937 T940 Y944 V948 M952 I953 V980
• Binding residue (residue number reindexed from 1): Y213 E226 G228 E229 R230 P232 Q233 P235 T238 Y242 V246 M250 I251 V278

Enzymatic activity

• Catalytic site (original residue number in PDB): D837 A839 R841 N842 D855 G874
• Catalytic site (residue number reindexed from 1): D135 A137 R139 N140 D153 G172
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:4i21, PDBe:4i21, PDBj:4i21
• PDBsum: 4i21
• PubMed: 23273428
• UniProt: P00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)