Structure of PDB 4hre Chain B Binding Site BS01

Receptor Information
>4hre Chain B (length=338) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGV
DEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILG
LLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMY
KTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDA
GVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGD
LENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDML
KIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hre SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.
Resolution2.7852 Å
Binding residue
(original residue number in PDB)		L11 S12 E36 D70 F73
Binding residue
(residue number reindexed from 1)		L10 S11 E35 D69 F72
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0004859 phospholipase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008092 cytoskeletal protein binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0042802 identical protein binding
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001765 membrane raft assembly
GO:0001921 positive regulation of receptor recycling
GO:0002091 negative regulation of receptor internalization
GO:0006900 vesicle budding from membrane
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0010756 positive regulation of plasminogen activation
GO:0014823 response to activity
GO:0030199 collagen fibril organization
GO:0030324 lung development
GO:0031340 positive regulation of vesicle fusion
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0036035 osteoclast development
GO:0042730 fibrinolysis
GO:0042789 mRNA transcription by RNA polymerase II
GO:0044090 positive regulation of vacuole organization
GO:0045921 positive regulation of exocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050767 regulation of neurogenesis
GO:1904019 epithelial cell apoptotic process
GO:1905581 positive regulation of low-density lipoprotein particle clearance
GO:1905597 positive regulation of low-density lipoprotein particle receptor binding
GO:1905599 positive regulation of low-density lipoprotein receptor activity
GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport
GO:1905686 positive regulation of plasma membrane repair
Cellular Component
GO:0001533 cornified envelope
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016363 nuclear matrix
GO:0030496 midbody
GO:0031902 late endosome membrane
GO:0035749 myelin sheath adaxonal region
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043220 Schmidt-Lanterman incisure
GO:0045121 membrane raft
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0090575 RNA polymerase II transcription regulator complex
GO:0098797 plasma membrane protein complex
GO:1990665 AnxA2-p11 complex
GO:1990667 PCSK9-AnxA2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hre, PDBe:4hre, PDBj:4hre
PDBsum4hre
PubMed23415230
UniProtP07356|ANXA2_MOUSE Annexin A2 (Gene Name=Anxa2)

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