Structure of PDB 4hon Chain B Binding Site BS01
Receptor Information
>4hon Chain B (length=330) Species:
9606
(Homo sapiens) [
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QNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARE
TYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQ
TPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQ
DLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKT
WYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPF
NRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCS
CGEARVTFSMDAFVRILQPERYDLWKRGQD
Ligand information
>4hon Chain G (length=7) Species:
9606
(Homo sapiens) [
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ARKSTGG
Receptor-Ligand Complex Structure
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PDB
4hon
Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases.
Resolution
1.799 Å
Binding residue
(original residue number in PDB)
Y89 H90 D139 E173 G174 Y179 Y181 K245 A292 N294 R316 V317
Binding residue
(residue number reindexed from 1)
Y78 H79 D128 E162 G163 Y168 Y170 K234 A281 N283 R305 V306
Enzymatic activity
Catalytic site (original residue number in PDB)
G174 Y181 H192 E194 H280 A292
Catalytic site (residue number reindexed from 1)
G163 Y170 H181 E183 H269 A281
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
External links
PDB
RCSB:4hon
,
PDBe:4hon
,
PDBj:4hon
PDBsum
4hon
PubMed
23219879
UniProt
Q6B0I6
|KDM4D_HUMAN Lysine-specific demethylase 4D (Gene Name=KDM4D)
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