Structure of PDB 4hda Chain B Binding Site BS01

Receptor Information
>4hda Chain B (length=270) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQA
QDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQG
RRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICP
ALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAIL
EEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPAT
NRFRFHFQGPCGTTLPEALA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hda A molecular mechanism for direct sirtuin activation by resveratrol.
Resolution2.601 Å
Binding residue
(original residue number in PDB)		R71 I142 H158 F223 G224 E225 N226 V254 Y255
Binding residue
(residue number reindexed from 1)		R39 I110 H126 F191 G192 E193 N194 V222 Y223
Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P36 T37 F38 R39 N109 D111 H126
Enzyme Commision number 2.3.1.-
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4hda, PDBe:4hda, PDBj:4hda
PDBsum4hda
PubMed23185430
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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