Structure of PDB 4gsl Chain B Binding Site BS01

Receptor Information
>4gsl Chain B (length=592) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SERVLSYAPAFKSFLDTSFFQELSRLKLDVLKLDSTCQPLTVNLDLHNIP
KSADQVPLFLTNRSFEKHNNKRTNEVPLQGSIFNFNVLDEFKNLDKQLFL
HQRALECWEDGIKDINKCVSFVIISFADLKKYRFYYWLGVPCFQRPSSTV
LHVRPEPSLKGLFSKCQKWFDVNYSKWVCILDADDEIVNYDKCIIRKTKV
LAIRDTSTMENVPSALTKNFLSVLQYDVPDLIDFKLLIIRQNEGSFALNA
TFASIDPQSSNPDMKVSGWERNVQGKLAPRVVDLSSLLDPLKIADQSVDL
NLKLMKWRILPDLNLDIIKNTKVLLLGAGTLGCYVSRALIAWGVRKITFV
DNGTVSYSNPVRQALYNFEDCGKPKAELAAASLKRIFPLMDATGVKLSIP
MIGHKLVNEEAQHKDFDRLRALIKEHDIIFLLVDSRESRWLPSLLSNIEN
KTVINAALGFDSYLVMRHGNQLGCYFCHDVVAPTDSLTDRTLDQMCTVTR
PGVAMMASSLAVELMTSLLQTKYSGSETTVLGDIPHQIRGFLHNFSILKL
ETPAYEHCPACSPKVIEAFTDLGWEFVKKALEHPLYLEEISG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4gsl Chain B Residue 700 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4gsl Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
Resolution2.703 Å
Binding residue
(original residue number in PDB)		C485 C488 C569
Binding residue
(residue number reindexed from 1)		C474 C477 C558
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0019778 Atg12 activating enzyme activity
GO:0019779 Atg8 activating enzyme activity
GO:0042802 identical protein binding
Biological Process
GO:0000422 autophagy of mitochondrion
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0015031 protein transport
GO:0016236 macroautophagy
GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway
GO:0032446 protein modification by small protein conjugation
GO:0034727 piecemeal microautophagy of the nucleus
GO:0043412 macromolecule modification
GO:0044804 nucleophagy
Cellular Component
GO:0000407 phagophore assembly site
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0097632 extrinsic component of phagophore assembly site membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4gsl, PDBe:4gsl, PDBj:4gsl
PDBsum4gsl
PubMed23142976
UniProtP38862|ATG7_YEAST Ubiquitin-like modifier-activating enzyme ATG7 (Gene Name=ATG7)

[Back to BioLiP]