Structure of PDB 4gs0 Chain B Binding Site BS01

Receptor Information
>4gs0 Chain B (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKN
QLLKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW
PEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYL
SWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIV
IDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQF
IETTKKKL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gs0 Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition.
Resolution1.7961 Å
Binding residue
(original residue number in PDB)		Y276 K277 N278 C453 S454 A455 I457 G458 R459 Q500
Binding residue
(residue number reindexed from 1)		Y17 K18 N19 C188 S189 A190 I192 G193 R194 Q235
Enzymatic activity
Catalytic site (original residue number in PDB) D419 C453 R459 T460 Q500
Catalytic site (residue number reindexed from 1) D154 C188 R194 T195 Q235
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gs0, PDBe:4gs0, PDBj:4gs0
PDBsum4gs0
PubMed23296072
UniProtP29350|PTN6_HUMAN Tyrosine-protein phosphatase non-receptor type 6 (Gene Name=PTPN6)

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