Structure of PDB 4gmk Chain B Binding Site BS01

Receptor Information

>4gmk Chain B (length=224) Species: 362948 (Ligilactobacillus salivarius UCC118)

DELKQLVGTKAVEWIKDGMIVGLGTGSTVKYMVDALGKRVNEEGLDIVGV
TTSIRTAEQAKSLGIVIKDIDEVDHIDLTIDGADEISSDFQGIKGGGAAL
LYEKIVATKSNKNMWIVDESKMVDDLGQFPLPVEVIPYGSGTVFKRFEEK
GLNPEFRKNEDGSLLHTDSDNYIIDLHLGKIENPKELGDYLINQVGVVEH
GLFLDIVNTVIVGRQDGPEVLEAR

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 4gmk Chain B Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4gmk Structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC118.
• Resolution: 1.72 Å
• Binding residue (original residue number in PDB): G29 S30 T31 K124
• Binding residue (residue number reindexed from 1): G26 S27 T28 K121
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.6: ribose-5-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0004751 ribose-5-phosphate isomerase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0006014 D-ribose metabolic process
• GO:0006098 pentose-phosphate shunt
• GO:0009052 pentose-phosphate shunt, non-oxidative branch
• GO:0044281 small molecule metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4gmk, PDBe:4gmk, PDBj:4gmk
• PDBsum: 4gmk
• PubMed: 23192019
• UniProt: Q1WR87