Structure of PDB 4ggd Chain B Binding Site BS01

Receptor Information
>4ggd Chain B (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSG
DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNM
TSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCG
LRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC
PWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL
ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAAD
ETLRLWRCFELD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ggd Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Resolution2.435 Å
Binding residue
(original residue number in PDB)		D184 Y185 Y186 Q310 N329 A357 G376 R445
Binding residue
(residue number reindexed from 1)		D20 Y21 Y22 Q146 N165 A193 G212 R281
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0010997 anaphase-promoting complex binding
GO:0097027 ubiquitin-protein transferase activator activity
Biological Process
GO:1904668 positive regulation of ubiquitin protein ligase activity

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Molecular Function
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Biological Process
External links
PDB RCSB:4ggd, PDBe:4ggd, PDBj:4ggd
PDBsum4ggd
PubMed23091007
UniProtQ12834|CDC20_HUMAN Cell division cycle protein 20 homolog (Gene Name=CDC20)

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