Structure of PDB 4gbx Chain B Binding Site BS01

Receptor Information

>4gbx Chain B (length=189) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VLFQGPGDTRPRFLWQLKFECHFFNGTERVRLLERSIYNQEESVRFDSDV
GEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCRHNYGVGESFTVQRR
VEPKVTVYPSHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA

Ligand information

>4gbx Chain E (length=10) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GKQNCLKLAT

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4gbx Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	F13 Y47 D57 Y60 W61 L67 R71 Y78 N82
Binding residue (residue number reindexed from 1)	F19 Y53 D63 Y66 W67 L73 R77 Y84 N88

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:4gbx, PDBe:4gbx, PDBj:4gbx
PDBsum	4gbx
PubMed	23260142
UniProt	P01911\|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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